Hood was a character with a multi-faceted personality. One website devoted to old-time radio wrote about him as follows:
Gregory Hood was also an accomplished pianist and composer, a self-taught forensics expert, spoke several languages fluently, was an expert in ancient and modern armament, had a military intelligence background, was a wine expert with an extensive rare wine cellar, and was an acknowledged expert in oriental tapestry. He lived in a penthouse on San Francisco's Nob Hill and employed a Chinese valet, Fong.
On June 3, 1946, The Casebook of Gregory Hood began on the Mutual Broadcasting System, replacing The New Adventures of Sherlock Holmes for the summer. Although intended to be just a summer replacement, it continued in the fall, sponsored by Petri Wine. Jeffrey Marks, in his biography of co-creator Anthony Boucher, explained, "The show had originally been planned as a summer replacement for The New Adventures of Sherlock Holmes in 1946, but continued for the next year when the radio network had difficulty in reaching an agreement with the Conan Doyle estate." The program had another full-season run on ABC in 1949-50 and also "resurfaced periodically in summer slots."
The show was written by Boucher and Denis Green, who also teamed to write the Holmes show. Marks provided this background:
Boucher and Green did such a good job for the Holmes show that they were asked about writing an original series for Mutual Radio. Radio shows relied on new episodes. Just as TV airs re-runs during the summer, radio shows gave their actors a summer hiatus of 13 weeks. Networks frequently ran original short-run programming during the summer. Boucher and Green came up with "The Casebook of Gregory Hood" a San Francisco-based antiquities expert who seemed to find current day crimes in the artifacts that he dealt with. The Casebook of Gregory Hood was nearly identical to The New Adventures of Sherlock Holmes in its opening: same sponsor, same announcement, same narrator frame for storytelling, and the same music. The narrator stopped by to visit Gregory either in his office or home, and the story was told by Hood. Hood's own Watson, Sandy Taylor, accompanied him. Taylor was Hood's lawyer and friend.
Gale Gordon played Gregory Hood in the initial version of the program. Others who had the leading role later were Elliott Lewis, Jackson Beck, Paul McGrath, Martin Gabel and George Petrie. Sidekick Sanderson Taylor was portrayed at various times by Art Gilmore, Carl Harbord, William Bakewell, Howard McNear and Bill Johnstone.